InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MIP

Summary

InnateDB Protein

IDBP-41088.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MIP

Protein Name

major intrinsic protein of lens fiber

Synonyms

AQP0; CTRCT15; LIM1; MIP26; MP26;

Species

Homo sapiens

Ensembl Protein

ENSP00000257979

InnateDB Gene

IDBG-41086 (MIP)

Protein Structure

UniProt Annotation

Function

Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Disease Associations

Cataract 15, multiple types (CTRCT15) [MIM:615274]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT15 includes polymorphic, progressive punctate lamellar, cortical, anterior and posterior polar, nonprogressive lamellar with sutural opacities, embryonic nuclear, and pulverulent cortical, among others. {ECO:0000269PubMed:10802646, ECO:0000269PubMed:11001937, ECO:0000269PubMed:16564824}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Major component of lens fiber gap junctions.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005212	structural constituent of eye lens
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0015250	water channel activity

Biological Process

GO:0002088	lens development in camera-type eye
GO:0006810	transport
GO:0006833	water transport
GO:0007601	visual perception
GO:0015722	canalicular bile acid transport
GO:0050896	response to stimulus
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005921	gap junction
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0046691	intracellular canaliculus