Version 5.4
Homo sapiens Protein: ASB14
Summary
InnateDB Protein IDBP-41190.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASB14
Protein Name ankyrin repeat and SOCS box containing 14
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000374252
InnateDB Gene IDBG-409168 (ASB14)
Protein Structure
UniProt Annotation
Function May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007242 intracellular signaling cascade
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001496 SOCS protein, C-terminal
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF07525
PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00253
SM00969
SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6NK59
PhosphoSite PhosphoSite-A6NK59
TrEMBL
UniProt Splice Variant
Entrez Gene 142686
UniGene Hs.740755
RefSeq NP_569058
HUGO HGNC:19766
OMIM
CCDS
HPRD 10668
IMGT
EMBL AC093928 AF403032 AL832472
GenPept AAL57351

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca