Version 5.4
Homo sapiens Protein: MTFP1
Summary
InnateDB Protein IDBP-4154.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTFP1
Protein Name mitochondrial fission process 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000347267
InnateDB Gene IDBG-402113 (MTFP1)
Protein Structure
UniProt Annotation
Function Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis. {ECO:0000269PubMed:15155745, ECO:0000269PubMed:15985469}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000305PubMed:15155745, ECO:0000305PubMed:15985469}; Multi- pass membrane protein {ECO:0000305PubMed:15155745, ECO:0000305PubMed:15985469}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
Biological Process
GO:0000266 mitochondrial fission
GO:0006915 apoptotic process
GO:0015976 carbon utilization
Cellular Component
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR019560 Mitochondrial 18kDa protein
PFAM PF10558
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UDX5
PhosphoSite PhosphoSite-Q9UDX5
TrEMBL
UniProt Splice Variant
Entrez Gene 51537
UniGene
RefSeq NP_001003704
HUGO HGNC:26945
OMIM 610235
CCDS CCDS33634
HPRD 17612
IMGT
EMBL AC004832 AF060924 AF151076 BC001608 BC009300 BC014446 BC030989 BC038831 BC046132 CR456345
GenPept AAF19257 AAF36162 AAG43136 AAH01608 AAH09300 AAH14446 AAH30989 AAH38831 AAH46132 CAG30231

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca