InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UQCRFS1

Summary

InnateDB Protein

IDBP-41698.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UQCRFS1

Protein Name

ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

Synonyms

RIP1; RIS1; RISP; UQCR5;

Species

Homo sapiens

Ensembl Protein

ENSP00000306397

InnateDB Gene

IDBG-41696 (UQCRFS1)

Protein Structure

UniProt Annotation

Function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex. {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008121	ubiquinol-cytochrome-c reductase activity
GO:0016491	oxidoreductase activity
GO:0032403	protein complex binding
GO:0046872	metal ion binding
GO:0051537	2 iron, 2 sulfur cluster binding

Biological Process

GO:0009725	response to hormone
GO:0022904	respiratory electron transport chain
GO:0042493	response to drug
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0046677	response to antibiotic
GO:0055114	oxidation-reduction process
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005750	mitochondrial respiratory chain complex III
GO:0031966	mitochondrial membrane

Protein Structure and Domains

PDB ID

InterPro

IPR004192 Ubiquinol cytochrome reductase, transmembrane domain
IPR005805 Rieske iron-sulphur protein, C-terminal
IPR006317 Ubiquinol-cytochrome c reductase, iron-sulphur subunit
IPR011070 Globular protein, non-globular alpha/beta subunit
IPR015248 Ubiquinol-cytochrome c reductase 8kDa, N-terminal
IPR017941 Rieske [2Fe-2S] iron-sulphur domain

PFAM

PF02921
PF09165
PF00355

PRINTS

PR00162

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P47985