InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NAB2

Summary

InnateDB Protein

IDBP-42029.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NAB2

Protein Name

NGFI-A binding protein 2 (EGR1 binding protein 2)

Synonyms

MADER;

Species

Homo sapiens

Ensembl Protein

ENSP00000300131

InnateDB Gene

IDBG-42027 (NAB2)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Isoform 2 is not localized to the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed at low levels. Highly expressed in melanoma cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	12 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0008134	transcription factor binding

Biological Process

GO:0001958	endochondral ossification
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007399	nervous system development
GO:0008283	cell proliferation
GO:0014037	Schwann cell differentiation
GO:0016480	negative regulation of transcription from RNA polymerase III promoter
GO:0042552	myelination
GO:0045682	regulation of epidermis development
GO:0045892	negative regulation of transcription, DNA-templated