InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GLG1

Summary

InnateDB Protein

IDBP-42041.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLG1

Protein Name

golgi glycoprotein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000205061

InnateDB Gene

IDBG-42039 (GLG1)

Protein Structure

UniProt Annotation

Function

Binds fibroblast growth factor and E-selectin (cell- adhesion lectin on endothelial cells mediating the binding of neutrophils).

Subcellular Localization

Golgi apparatus membrane {ECO:0000269PubMed:2355176}; Single-pass type I membrane protein {ECO:0000269PubMed:2355176}.

Disease Associations

Tissue Specificity

Widely expressed. Highest levels in pancreas, skeletal muscle, placenta, heart, testis and ovary. Also found in the kidney, liver, lung and brain. {ECO:0000269PubMed:9182700}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding

Biological Process

GO:0007596	blood coagulation
GO:0010955	negative regulation of protein processing
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032330	regulation of chondrocyte differentiation
GO:0050900	leukocyte migration
GO:0060349	bone morphogenesis

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome