InnateDB Protein
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IDBP-42172.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AKR1B1
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Protein Name
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aldo-keto reductase family 1, member B1 (aldose reductase)
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Synonyms
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ADR; ALDR1; ALR2; AR;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000285930
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InnateDB Gene
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IDBG-42170 (AKR1B1)
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Protein Structure
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Function |
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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Subcellular Localization |
Cytoplasm.
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Disease Associations |
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Tissue Specificity |
Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress. {ECO:0000269PubMed:8435445}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
14
[view]
|
Protein-Protein |
11
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0004032
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alditol:NADP+ 1-oxidoreductase activity
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GO:0004033
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aldo-keto reductase (NADP) activity
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GO:0009055
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electron carrier activity
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GO:0043795
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glyceraldehyde oxidoreductase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR020471
Aldo/keto reductase subgroup
IPR023210
NADP-dependent oxidoreductase domain
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PFAM |
PF00248
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PRINTS |
PR00069
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PIRSF |
PIRSF000097
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P15121
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PhosphoSite |
PhosphoSite-P15121
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TrEMBL |
O15289
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UniProt Splice Variant |
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Entrez Gene |
231
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UniGene |
Hs.602524
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RefSeq |
NP_001619
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HUGO |
HGNC:381
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OMIM |
103880
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CCDS |
CCDS5831
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HPRD |
00071
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IMGT |
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EMBL |
AF032455
AF328729
AK313439
BC000260
BC005387
BC010391
BT019859
CH236950
CH471070
CR450351
CR542203
J04795
J05017
J05474
M34720
M34721
M59783
M59856
U72619
X15414
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GenPept |
AAA35560
AAA35561
AAA51712
AAA51713
AAA51714
AAA51715
AAB61992
AAB88851
AAH00260
AAH05387
AAH10391
AAN09721
AAV38662
BAG36230
CAA33460
CAG29347
CAG47000
EAL24070
EAW83814
EAW83815
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