InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANKRD27

Summary

InnateDB Protein

IDBP-42214.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANKRD27

Protein Name

ankyrin repeat domain 27 (VPS9 domain)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000304292

InnateDB Gene

IDBG-42212 (ANKRD27)

Protein Structure

UniProt Annotation

Function

May be a Rab21 guanine exchange factor and regulate endosome dynamics. {ECO:0000250}.

Subcellular Localization

Cytoplasm. Note=Mainly localized to early endosomes in the perinuclear region. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0043547	positive regulation of GTPase activity
GO:0045022	early endosome to late endosome transport

Cellular Component

GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005769	early endosome
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002110 Ankyrin repeat
IPR003123 Vacuolar sorting protein 9
IPR013995 Vacuolar sorting protein 9, subgroup
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00023
PF13606
PF02204
PF11929
PF12796

PRINTS

PR01415

PIRSF

SMART

SM00248
SM00167

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt