InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL5

Summary

InnateDB Protein

IDBP-42238.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL5

Protein Name

interleukin 5 (colony-stimulating factor, eosinophil)

Synonyms

EDF; IL-5; TRF;

Species

Homo sapiens

Ensembl Protein

ENSP00000231454

InnateDB Gene

IDBG-42236 (IL5)

Protein Structure

UniProt Annotation

Function

Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005137	interleukin-5 receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0006954	inflammatory response
GO:0006955	immune response
GO:0008284	positive regulation of cell proliferation
GO:0019221	cytokine-mediated signaling pathway
GO:0030890	positive regulation of B cell proliferation
GO:0045645	positive regulation of eosinophil differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046427	positive regulation of JAK-STAT cascade
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051024	positive regulation of immunoglobulin secretion
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0071803	positive regulation of podosome assembly