InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GLI1

Summary

InnateDB Protein

IDBP-42579.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLI1

Protein Name

GLI family zinc finger 1

Synonyms

GLI;

Species

Homo sapiens

Ensembl Protein

ENSP00000228682

InnateDB Gene

IDBG-42577 (GLI1)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation. {ECO:0000269PubMed:10806483, ECO:0000269PubMed:11238441}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted by interaction with ZIC1.

Disease Associations

Tissue Specificity

Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract. {ECO:0000269PubMed:19878745}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	32 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0006366	transcription from RNA polymerase II promoter
GO:0007224	smoothened signaling pathway
GO:0007283	spermatogenesis
GO:0007418	ventral midline development
GO:0008284	positive regulation of cell proliferation
GO:0008589	regulation of smoothened signaling pathway
GO:0009913	epidermal cell differentiation
GO:0009953	dorsal/ventral pattern formation
GO:0009954	proximal/distal pattern formation
GO:0021696	cerebellar cortex morphogenesis
GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021983	pituitary gland development
GO:0030324	lung development
GO:0045087	innate immune response (InnateDB)
GO:0045740	positive regulation of DNA replication
GO:0045880	positive regulation of smoothened signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048546	digestive tract morphogenesis
GO:0060032	notochord regression
GO:0090090	negative regulation of canonical Wnt signaling pathway