Version 5.4
Homo sapiens Protein: MBD6
Summary
InnateDB Protein IDBP-42847.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MBD6
Protein Name methyl-CpG binding domain protein 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000347896
InnateDB Gene IDBG-42845 (MBD6)
Protein Structure
UniProt Annotation
Function Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).
Subcellular Localization Nucleus {ECO:0000269PubMed:20700456}. Chromosome {ECO:0000269PubMed:20700456}. Note=Associated with pericentric heterochromatin in about 25% of the cells.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0010369 chromocenter
Protein Structure and Domains
PDB ID
InterPro IPR001739 Methyl-CpG DNA binding
IPR016177 DNA-binding domain
PFAM PF01429
PRINTS
PIRSF
SMART SM00391
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96DN6
PhosphoSite PhosphoSite-Q96DN6
TrEMBL F8VZD7
UniProt Splice Variant
Entrez Gene 114785
UniGene Hs.740813
RefSeq NP_443129
HUGO HGNC:20445
OMIM
CCDS CCDS8944
HPRD 11296
IMGT
EMBL AB067474 AC022506 AK056399 AK093078 AL834230 CH471054
GenPept BAB67780 BAB71176 BAC04045 CAD38908 EAW97024 EAW97025

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca