InnateDB Protein
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IDBP-43163.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DPY30
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Protein Name
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dpy-30 homolog (C. elegans)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000295066
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InnateDB Gene
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IDBG-43159 (DPY30)
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Protein Structure
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Function |
As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. {ECO:0000269PubMed:19556245, ECO:0000269PubMed:19651892, ECO:0000269PubMed:21335234}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:19651892}. Golgi apparatus, trans-Golgi network {ECO:0000269PubMed:19651892}. Note=Associated with chromatin at regions enriched in histone H3 trimethylated at 'Lys-4. Highly enriched in gene promoter regions and 5' UTRs, but not in downstream regions of genes or 3' UTRs (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
56
[view]
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Protein-Protein |
55
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007858
Dpy-30 motif
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PFAM |
PF05186
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9C005
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PhosphoSite |
PhosphoSite-Q9C005
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
84661
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UniGene |
Hs.645042
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RefSeq |
NP_115963
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HUGO |
HGNC:24590
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OMIM |
612032
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CCDS |
CCDS1777
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HPRD |
17434
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IMGT |
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EMBL |
AF226998
BC015970
CH471053
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GenPept |
AAH15970
AAK00640
EAX00463
EAX00466
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