InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TKTL2

Summary

InnateDB Protein

IDBP-43295.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TKTL2

Protein Name

transketolase-like 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000280605

InnateDB Gene

IDBG-43293 (TKTL2)

Protein Structure

UniProt Annotation

Function

Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis. {ECO:0000269PubMed:17321041}.

Subcellular Localization

Disease Associations

Tissue Specificity

Overexpressed in hepatoma cancer cells. {ECO:0000269PubMed:17321041}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004802	transketolase activity
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0046872	metal ion binding

Biological Process

GO:0008152

metabolic process

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001017 Dehydrogenase, E1 component
IPR005474 Transketolase, N-terminal
IPR005475 Transketolase-like, pyrimidine-binding domain
IPR005476 Transketolase, C-terminal
IPR009014 Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II
IPR029061 Thiamin diphosphate-binding fold

PFAM

PF00676
PF00456
PF02779
PF02780

PRINTS

PIRSF

SMART

SM00861

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9H0I9