InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MARCH1

Summary

InnateDB Protein

IDBP-43341.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MARCH1

Protein Name

membrane-associated ring finger (C3HC4) 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000274056

InnateDB Gene

IDBG-43339 (MARCH1)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. {ECO:0000269PubMed:14722266, ECO:0000269PubMed:18305173, ECO:0000269PubMed:18389477, ECO:0000269PubMed:19117940}.

Subcellular Localization

Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in antigen presenting cells, APCs, located in lymph nodes and spleen. Also expressed in lung. Expression is high in follicular B-cells, moderate in dendritic cells and low in splenic T-cells. {ECO:0000269PubMed:14722266, ECO:0000269PubMed:17255932}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0042287	MHC protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0002495	antigen processing and presentation of peptide antigen via MHC class II
GO:0006955	immune response

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0031901	early endosome membrane
GO:0031902	late endosome membrane
GO:0032588	trans-Golgi network membrane