InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KANK1

Summary

InnateDB Protein

IDBP-43692.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KANK1

Protein Name

KN motif and ankyrin repeat domains 1

Synonyms

ANKRD15; CPSQ2; KANK;

Species

Homo sapiens

Ensembl Protein

ENSP00000371734

InnateDB Gene

IDBG-43688 (KANK1)

Protein Structure

UniProt Annotation

Function

Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. {ECO:0000269PubMed:16968744, ECO:0000269PubMed:18458160, ECO:0000269PubMed:19171758, ECO:0000269PubMed:22084092}.

Subcellular Localization

Cell projection, ruffle membrane {ECO:0000269PubMed:12133830, ECO:0000269PubMed:16968744}. Note=Colocalizes with KIF21A in membrane ruffles.Isoform 1: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and nucleus.Isoform 2: Cytoplasm. Nucleus. Cell projection, ruffle membrane. Note=Shuttles between the cytoplasm and nucleus.

Disease Associations

Cerebral palsy, spastic quadriplegic 2 (CPSQ2) [MIM:612900]: A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest congenital hypotonia evolving over the first year to spastic quadriplegia with accompanying transient nystagmus and varying degrees of mental retardation. Neuroimaging shows brain atrophy and ventriculomegaly. {ECO:0000269PubMed:16301218}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed. Isoform 1 is predominantly expressed in heart and kidney. Isoform 2 probably is widely expressed at basic levels. {ECO:0000269PubMed:15823577}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008013	beta-catenin binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0010977	negative regulation of neuron projection development
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030336	negative regulation of cell migration
GO:0030837	negative regulation of actin filament polymerization
GO:0035024	negative regulation of Rho protein signal transduction
GO:0035413	positive regulation of catenin import into nucleus
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0090303	positive regulation of wound healing
GO:1900025	negative regulation of substrate adhesion-dependent cell spreading
GO:1900028	negative regulation of ruffle assembly
GO:2000114	regulation of establishment of cell polarity
GO:2000393	negative regulation of lamellipodium morphogenesis