InnateDB Protein
|
IDBP-43733.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
MARCH9
|
Protein Name
|
membrane-associated ring finger (C3HC4) 9
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000266643
|
InnateDB Gene
|
IDBG-43731 (MARCH9)
|
Protein Structure
|
|
Function |
E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000269PubMed:14722266, ECO:0000269PubMed:17174307}.
|
Subcellular Localization |
Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
|
Disease Associations |
|
Tissue Specificity |
Ubiquitously expressed. {ECO:0000269PubMed:14722266}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
6
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR011016
Zinc finger, RING-CH-type
IPR018957
Zinc finger, C3HC4 RING-type
|
PFAM |
PF12906
PF00097
|
PRINTS |
|
PIRSF |
|
SMART |
SM00744
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q86YJ5
|
PhosphoSite |
PhosphoSite-Q86YJ5
|
TrEMBL |
Q8N9T1
|
UniProt Splice Variant |
|
Entrez Gene |
92979
|
UniGene |
Hs.632709
|
RefSeq |
NP_612405
|
HUGO |
HGNC:25139
|
OMIM |
613336
|
CCDS |
CCDS31847
|
HPRD |
14360
|
IMGT |
|
EMBL |
AK093897
AK313925
BC009489
BC036455
BC050397
CH471054
|
GenPept |
AAH09489
AAH36455
AAH50397
BAC04247
BAG36646
EAW97065
|
|
|