Version 5.4
Homo sapiens Protein: C1QTNF4
Summary
InnateDB Protein IDBP-43754.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C1QTNF4
Protein Name C1q and tumor necrosis factor related protein 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000302274
InnateDB Gene IDBG-43752 (C1QTNF4)
Protein Structure
UniProt Annotation
Function May act as a pro-inflammatory cytokine, that induces the activation of NF-kappa-B signaling pathway and up-regulates IL6 production. {ECO:0000269PubMed:21658842}.
Subcellular Localization Secreted {ECO:0000269PubMed:21658842}.
Disease Associations
Tissue Specificity Widely expressed at low levels. {ECO:0000269PubMed:21658842}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR001073 Complement C1q protein
IPR008983 Tumour necrosis factor-like domain
PFAM PF00386
PRINTS PR00007
PIRSF
SMART SM00110
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BXJ3
PhosphoSite PhosphoSite-Q9BXJ3
TrEMBL E9PPZ5
UniProt Splice Variant
Entrez Gene 114900
UniGene
RefSeq NP_114115
HUGO HGNC:14346
OMIM 614911
CCDS CCDS7942
HPRD 12717
IMGT
EMBL AC104942 AF329838 BC035628
GenPept AAH35628 AAK17962

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca