Version 5.4
Homo sapiens Protein: MPHOSPH6
Summary
InnateDB Protein IDBP-43869.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MPHOSPH6
Protein Name M-phase phosphoprotein 6
Synonyms MPP; MPP-6; MPP6;
Species Homo sapiens
Ensembl Protein ENSP00000258169
InnateDB Gene IDBG-43867 (MPHOSPH6)
Protein Structure
UniProt Annotation
Function RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D. {ECO:0000269PubMed:17412707}.
Subcellular Localization Nucleus, nucleolus. Cytoplasm. Note=Cytoplasmic in M phase.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 30 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000087 mitotic M phase
GO:0000460 maturation of 5.8S rRNA
Cellular Component
GO:0000176 nuclear exosome (RNase complex)
GO:0000178 exosome (RNase complex)
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR019324 M-phase phosphoprotein 6
PFAM PF10175
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99547
PhosphoSite PhosphoSite-Q99547
TrEMBL H3BNT4
UniProt Splice Variant
Entrez Gene 10200
UniGene Hs.601155
RefSeq NP_005783
HUGO HGNC:7214
OMIM 605500
CCDS CCDS10937
HPRD 16111
IMGT
EMBL AC138304 AK314163 BC005242 BC011020 BC031017 CH471114 X98263
GenPept AAH05242 AAH11020 AAH31017 BAG36847 CAA66916 EAW95517

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca