Version 5.4
Homo sapiens Protein: RBMY1A1
Summary
InnateDB Protein IDBP-444.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBMY1A1
Protein Name RNA binding motif protein, Y-linked, family 1, member A1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000372154
InnateDB Gene IDBG-298183 (RBMY1A1)
Protein Structure
UniProt Annotation
Function RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. {ECO:0000269PubMed:12165565, ECO:0000269PubMed:8269511}.
Subcellular Localization Nucleus {ECO:0000269PubMed:9108067}.
Disease Associations
Tissue Specificity Testis-specific. {ECO:0000269PubMed:8269511}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
Biological Process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0007283 spermatogenesis
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
IPR012604 RBM1CTR
PFAM PF00076
PF08081
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P0DJD3
PhosphoSite PhosphoSite-P0DJD3
TrEMBL J3QTP2
UniProt Splice Variant
Entrez Gene 5940
UniGene Hs.694476
RefSeq NP_005049
HUGO HGNC:9912
OMIM 400006
CCDS CCDS14796
HPRD 02450
IMGT
EMBL AC010141 BC047768 BC070298 X76059
GenPept AAH47768 AAH70298 CAA53659

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca