InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAS2R3

Summary

InnateDB Protein

IDBP-44557.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAS2R3

Protein Name

taste receptor, type 2, member 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000247879

InnateDB Gene

IDBG-44555 (TAS2R3)

Protein Structure

UniProt Annotation

Function

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. {ECO:0000269PubMed:10761934, ECO:0000269PubMed:10761935}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells. Expressed in the antrum and fundus (part of the stomach), duodenum and in gastric endocrine cells. {ECO:0000269PubMed:10761934}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0008527	taste receptor activity
GO:0033038	bitter taste receptor activity

Biological Process

GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0050909	sensory perception of taste