InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AVPR1A

Summary

InnateDB Protein

IDBP-44563.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AVPR1A

Protein Name

arginine vasopressin receptor 1A

Synonyms

AVPR V1a; AVPR1; V1aR;

Species

Homo sapiens

Ensembl Protein

ENSP00000299178

InnateDB Gene

IDBG-44561 (AVPR1A)

Protein Structure

UniProt Annotation

Function

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. {ECO:0000269PubMed:12082568}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005000	vasopressin receptor activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0017046	peptide hormone binding
GO:0031894	V1A vasopressin receptor binding

Biological Process

GO:0001992	regulation of systemic arterial blood pressure by vasopressin
GO:0002125	maternal aggressive behavior
GO:0003084	positive regulation of systemic arterial blood pressure
GO:0006091	generation of precursor metabolites and energy
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007621	negative regulation of female receptivity
GO:0007625	grooming behavior
GO:0008015	blood circulation
GO:0008284	positive regulation of cell proliferation
GO:0010033	response to organic substance
GO:0010035	response to inorganic substance
GO:0010460	positive regulation of heart rate
GO:0014049	positive regulation of glutamate secretion
GO:0014902	myotube differentiation
GO:0019722	calcium-mediated signaling
GO:0021537	telencephalon development
GO:0030307	positive regulation of cell growth
GO:0031394	positive regulation of prostaglandin biosynthetic process
GO:0032849	positive regulation of cellular pH reduction
GO:0035176	social behavior
GO:0035815	positive regulation of renal sodium excretion
GO:0042631	cellular response to water deprivation
GO:0042711	maternal behavior
GO:0042713	sperm ejaculation
GO:0043084	penile erection
GO:0045777	positive regulation of blood pressure
GO:0045907	positive regulation of vasoconstriction
GO:0051412	response to corticosterone
GO:0051970	negative regulation of transmission of nerve impulse

Cellular Component

GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0031410	cytoplasmic vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001224 Vasopressin V1A receptor
IPR001817 Vasopressin receptor
IPR015076 Domain of unknown function DUF1856
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)

PFAM

PF00001
PF08983
PF10320
PF10323

PRINTS

PR00237
PR00752
PR00896

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P37288