InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GTPBP4

Summary

InnateDB Protein

IDBP-44609.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GTPBP4

Protein Name

GTP binding protein 4

Synonyms

CRFG; NGB; NOG1;

Species

Homo sapiens

Ensembl Protein

ENSP00000354040

InnateDB Gene

IDBG-44603 (GTPBP4)

Protein Structure

UniProt Annotation

Function

Involved in the biogenesis of the 60S ribosomal subunit. {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:11316846, ECO:0000269PubMed:12429849, ECO:0000269Ref.8}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	40 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0015093	ferrous iron transmembrane transporter activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001649	osteoblast differentiation
GO:0006184	GTP catabolic process
GO:0007264	small GTPase mediated signal transduction
GO:0008156	negative regulation of DNA replication
GO:0008285	negative regulation of cell proliferation
GO:0015684	ferrous iron transport
GO:0022408	negative regulation of cell-cell adhesion
GO:0030336	negative regulation of cell migration
GO:0031397	negative regulation of protein ubiquitination
GO:0033342	negative regulation of collagen binding
GO:0042254	ribosome biogenesis
GO:0050821	protein stabilization

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR005225 Small GTP-binding protein domain
IPR006073 GTP binding domain
IPR010674 Nucleolar GTP-binding protein 1, Rossman-fold domain
IPR011619 Ferrous iron transport protein B, N-terminal
IPR012973 NOG, C-terminal
IPR013684 Mitochondrial Rho-like
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01926
PF06858
PF02421
PF08155
PF08477

PRINTS

PR00326

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BZE4