InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE2B

Summary

InnateDB Protein

IDBP-44829.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2B

Protein Name

ubiquitin-conjugating enzyme E2B

Synonyms

E2-17kDa; HHR6B; HR6B; RAD6B; UBC2;

Species

Homo sapiens

Ensembl Protein

ENSP00000265339

InnateDB Gene

IDBG-44827 (UBE2B)

Protein Structure

UniProt Annotation

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys- 164'. May be involved in neurite outgrowth. {ECO:0000269PubMed:16337599, ECO:0000269PubMed:17108083, ECO:0000269PubMed:17130289, ECO:0000269PubMed:1717990, ECO:0000269PubMed:20061386}.

Subcellular Localization

Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}. Note=In peripheral neurons, expressed both at the plasma membrane and in nuclei. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	72 [view]
Protein-Protein	71 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0006281	DNA repair
GO:0006301	postreplication repair
GO:0006344	maintenance of chromatin silencing
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006513	protein monoubiquitination
GO:0006974	cellular response to DNA damage stimulus
GO:0007283	spermatogenesis
GO:0007288	sperm axoneme assembly
GO:0009411	response to UV
GO:0010845	positive regulation of reciprocal meiotic recombination
GO:0016567	protein ubiquitination
GO:0031056	regulation of histone modification
GO:0032869	cellular response to insulin stimulus
GO:0033128	negative regulation of histone phosphorylation
GO:0033522	histone H2A ubiquitination
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043951	negative regulation of cAMP-mediated signaling
GO:0050821	protein stabilization
GO:0051026	chiasma assembly
GO:0051865	protein autoubiquitination
GO:0060070	canonical Wnt signaling pathway
GO:0070076	histone lysine demethylation
GO:0070193	synaptonemal complex organization
GO:0070534	protein K63-linked ubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0070979	protein K11-linked ubiquitination

Cellular Component

GO:0000785	chromatin
GO:0000790	nuclear chromatin
GO:0001741	XY body
GO:0005634	nucleus
GO:0005657	replication fork
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0033503	HULC complex