InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYOM1

Summary

InnateDB Protein

IDBP-449.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYOM1

Protein Name

myomesin 1, 185kDa

Synonyms

SKELEMIN;

Species

Homo sapiens

Ensembl Protein

ENSP00000348821

InnateDB Gene

IDBG-447 (MYOM1)

Protein Structure

UniProt Annotation

Function

Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.

Subcellular Localization

Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008307	structural constituent of muscle
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006936

muscle contraction

Cellular Component

GO:0005863	striated muscle myosin thick filament
GO:0030017	sarcomere
GO:0031430	M band

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set

PFAM

PF00041
PF01108
PF07679

PRINTS

PIRSF

SMART

SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P52179