Version 5.4
Homo sapiens Protein: PPP4R2
Summary
InnateDB Protein IDBP-44966.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP4R2
Protein Name protein phosphatase 4, regulatory subunit 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000349124
InnateDB Gene IDBG-44962 (PPP4R2)
Protein Structure
UniProt Annotation
Function Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. {ECO:0000269PubMed:10769191, ECO:0000269PubMed:12668731, ECO:0000269PubMed:18614045, ECO:0000269PubMed:20154705}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=Ionizing radiation induces relocalization to nuclear foci and colocalization with RPA2.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:12668731}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030362 protein phosphatase type 4 regulator activity
GO:0030674 protein binding, bridging
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006397 mRNA processing
GO:0006464 cellular protein modification process
GO:0008380 RNA splicing
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0030289 protein phosphatase 4 complex
Protein Structure and Domains
PDB ID
InterPro IPR015267 Protein phosphatase 4 core regulatory subunit R2
PFAM PF09184
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NY27
PhosphoSite PhosphoSite-Q9NY27
TrEMBL F8WDK3
UniProt Splice Variant
Entrez Gene 151987
UniGene Hs.626271
RefSeq NP_777567
HUGO HGNC:18296
OMIM 613822
CCDS CCDS2917
HPRD 11453
IMGT
EMBL AC098481 AC103559 AF327345 AJ271448 AK289901 BC100281 BC110889 BC128136 BC128137 CH471055
GenPept AAI00282 AAI10890 AAI28137 AAI28138 AAL56006 BAF82590 CAB93534 EAW65530

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca