InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DDX46

Summary

InnateDB Protein

IDBP-45112.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX46

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 46

Synonyms

Prp5; PRPF5;

Species

Homo sapiens

Ensembl Protein

ENSP00000346236

InnateDB Gene

IDBG-45108 (DDX46)

Protein Structure

UniProt Annotation

Function

Plays an essential role in splicing, either prior to, or during splicing A complex formation. {ECO:0000269PubMed:12234937}.

Subcellular Localization

Nucleus speckle {ECO:0000269PubMed:12234937}. Nucleus, Cajal body {ECO:0000269PubMed:12234937}. Note=Present in Cajal bodies (CBs) and nuclear speckles.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.

Experimentally validated
Total	28 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006397	mRNA processing
GO:0008380	RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0015030	Cajal body
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7L014