Version 5.4
Homo sapiens Protein: COX4I1
Summary
InnateDB Protein IDBP-45245.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COX4I1
Protein Name cytochrome c oxidase subunit IV isoform 1
Synonyms COX4; COX4-1; COXIV;
Species Homo sapiens
Ensembl Protein ENSP00000253452
InnateDB Gene IDBG-45243 (COX4I1)
Protein Structure
UniProt Annotation
Function This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular Localization Mitochondrion inner membrane.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 9 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004129 cytochrome-c oxidase activity
GO:0005515 protein binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0022904 respiratory electron transport chain
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR004203 Cytochrome c oxidase subunit IV family
IPR013288 Cytochrome c oxidase subunit IV
PFAM PF02936
PRINTS PR01873
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P13073
PhosphoSite PhosphoSite-P13073
TrEMBL H3BPG0
UniProt Splice Variant
Entrez Gene 1327
UniGene
RefSeq NP_001852
HUGO HGNC:2265
OMIM 123864
CCDS CCDS10955
HPRD 00466
IMGT
EMBL AC018695 AF005889 AF017115 AH005828 AK311847 BC008704 BC021236 BC062437 BT019825 CH471114 M21575 M34600 U90915 X54802
GenPept AAA52059 AAA99312 AAB51058 AAB94819 AAB97750 AAC99578 AAH08704 AAH21236 AAH62437 AAV38628 BAG34789 CAA38573 EAW95437 EAW95438

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca