InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRKD3

Summary

InnateDB Protein

IDBP-45518.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKD3

Protein Name

protein kinase D3

Synonyms

EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN;

Species

Homo sapiens

Ensembl Protein

ENSP00000234179

InnateDB Gene

IDBG-45514 (PRKD3)

Protein Structure

UniProt Annotation

Function

Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18076381}. Membrane {ECO:0000269PubMed:18076381}. Note=Translocation to the cell membrane is required for kinase activation.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004697	protein kinase C activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0009103	lipopolysaccharide biosynthetic process
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR020454 Diacylglycerol/phorbol-ester binding
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00169
PF00130
PF06293

PRINTS

PR00109
PR00008

PIRSF

SMART

SM00233
SM00109
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt