InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: QPCT

Summary

InnateDB Protein

IDBP-45694.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

QPCT

Protein Name

glutaminyl-peptide cyclotransferase

Synonyms

GCT; QC; sQC;

Species

Homo sapiens

Ensembl Protein

ENSP00000344829

InnateDB Gene

IDBG-45690 (QPCT)

Protein Structure

UniProt Annotation

Function

Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides. {ECO:0000269PubMed:15063747, ECO:0000269PubMed:18486145, ECO:0000269PubMed:21288892}.

Subcellular Localization

Secreted {ECO:0000269PubMed:18486145}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008233	peptidase activity
GO:0008270	zinc ion binding
GO:0016603	glutaminyl-peptide cyclotransferase activity

Biological Process

GO:0006464	cellular protein modification process
GO:0006508	proteolysis
GO:0017186	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase