Version 5.4
Homo sapiens Protein: TRAPPC11
Summary
InnateDB Protein IDBP-46085.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRAPPC11
Protein Name chromosome 4 open reading frame 41
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000349738
InnateDB Gene IDBG-46081 (TRAPPC11)
Protein Structure
UniProt Annotation
Function Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. {ECO:0000269PubMed:21525244}.
Subcellular Localization Golgi apparatus, cis-Golgi network {ECO:0000250}.
Disease Associations Limb-girdle muscular dystrophy 2S (LGMD2S) [MIM:615356]: A form of limb-girdle muscular dystrophy characterized by proximal muscle weakness with childhood onset, resulting in gait abnormalities and scapular winging. Serum creatine kinase is increased. A subset of patients may show a hyperkinetic movement disorder with chorea, ataxia, or dystonia and global developmental delay. {ECO:0000269PubMed:23830518}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005794 Golgi apparatus
Protein Structure and Domains
PDB ID
InterPro IPR012880 Domain of unknown function DUF1683, C-terminal
IPR021773 Foie gras liver health family 1
PFAM PF07919
PF11817
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z392
PhosphoSite PhosphoSite-Q7Z392
TrEMBL
UniProt Splice Variant
Entrez Gene 60684
UniGene Hs.739142
RefSeq NP_951008
HUGO HGNC:25751
OMIM 614138
CCDS CCDS47166
HPRD 10968
IMGT
EMBL AK022778 AK023390 AK026992 AK315057 AL136752 AL833571 BC051724 BC139745 BX538044 CR533553
GenPept AAH51724 AAI39746 BAB14240 BAB14556 BAB15617 BAG37533 CAB66686 CAD91169 CAD97983 CAG38584

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca