InnateDB Protein
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IDBP-46093.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GPR18
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Protein Name
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G protein-coupled receptor 18
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000343428
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InnateDB Gene
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IDBG-46091 (GPR18)
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Protein Structure
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Function |
Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system. {ECO:0000269PubMed:16844083}.
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Subcellular Localization |
Cell membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Most abundant in testis and spleen. Highly expressed in CD4 and CD8-positive T-cells as well as CD19-positive B-cells. {ECO:0000269PubMed:16844083}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004930
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G-protein coupled receptor activity
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Biological Process |
GO:0007186
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G-protein coupled receptor signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like
IPR017452
GPCR, rhodopsin-like, 7TM
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PFAM |
PF00001
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PRINTS |
PR00237
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q14330
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PhosphoSite |
PhosphoSite-Q14330
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TrEMBL |
Q5JUH9
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UniProt Splice Variant |
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Entrez Gene |
2841
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UniGene |
Hs.741589
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RefSeq |
XP_006720009
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HUGO |
HGNC:4472
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OMIM |
602042
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CCDS |
CCDS9491
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HPRD |
03621
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IMGT |
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EMBL |
AF261135
AL160155
BC008569
BC050646
BC066927
BT009907
CH471085
JQ308176
L42324
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GenPept |
AAB65819
AAG44671
AAH08569
AAH50646
AAH66927
AAP88909
AFF59486
CAI14306
EAX09017
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