InnateDB Protein
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IDBP-46102.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SDHAF1
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Protein Name
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succinate dehydrogenase complex assembly factor 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000368165
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InnateDB Gene
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IDBG-46100 (SDHAF1)
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Protein Structure
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Function |
Plays an essential role in succinate dehydrogenase complex (SDH) assembly, a complex involved in complex II of the mitochondrial electron transport chain. Probably acts by participating in mitochondrial biosynthesis of iron-sulfur centers for complex II (Probable). {ECO:0000305PubMed:19465911}.
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Subcellular Localization |
Mitochondrion matrix {ECO:0000305PubMed:19465911}.
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Disease Associations |
Mitochondrial complex II deficiency (MT-C2D) [MIM:252011]: A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations. Clinical features include psychomotor regression in infants, poor growth with lack of speech development, severe spastic quadriplegia, dystonia, progressive leukoencephalopathy, muscle weakness, exercise intolerance, cardiomyopathy. Some patients manifest Leigh syndrome or Kearns-Sayre syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Ubiquitously expressed. {ECO:0000269PubMed:19465911}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
GO:0016226
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iron-sulfur cluster assembly
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GO:0034553
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mitochondrial respiratory chain complex II assembly
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Cellular Component |
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PDB ID |
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InterPro |
IPR008011
Complex 1 LYR protein
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PFAM |
PF05347
PF13232
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
A6NFY7
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PhosphoSite |
PhosphoSite-A6NFY7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
644096
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UniGene |
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RefSeq |
NP_001036096
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HUGO |
HGNC:33867
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OMIM |
612848
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CCDS |
CCDS32999
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HPRD |
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IMGT |
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EMBL |
AF038458
BC137516
BC137517
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GenPept |
AAI37517
AAI37518
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