InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DRG1

Summary

InnateDB Protein

IDBP-4650.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DRG1

Protein Name

developmentally regulated GTP binding protein 1

Synonyms

NEDD3;

Species

Homo sapiens

Ensembl Protein

ENSP00000329715

InnateDB Gene

IDBG-4648 (DRG1)

Protein Structure

UniProt Annotation

Function

Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15676025, ECO:0000269PubMed:19819225}. Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes.

Disease Associations

Tissue Specificity

High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes. {ECO:0000269PubMed:10760581}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	29 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008134	transcription factor binding
GO:0015093	ferrous iron transmembrane transporter activity
GO:0042802	identical protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0015684	ferrous iron transport

Cellular Component

GO:0005737	cytoplasm
GO:0005844	polysome
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR004095 TGS
IPR005225 Small GTP-binding protein domain
IPR006073 GTP binding domain
IPR011619 Ferrous iron transport protein B, N-terminal
IPR012676 TGS-like
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02824
PF01926
PF02421

PRINTS

PR00326

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y295