Homo sapiens Protein: PRG3
Summary
InnateDB Protein IDBP-46520.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRG3
Protein Name proteoglycan 3
Synonyms MBP2; MBPH;
Species Homo sapiens
Ensembl Protein ENSP00000287143
InnateDB Gene IDBG-46518 (PRG3)
Protein Structure
UniProt Annotation
Function Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils. {ECO:0000269PubMed:10318872}.
Subcellular Localization Cytoplasmic granule {ECO:0000269PubMed:10318872}. Note=Localized to the eosinophil secondary granule.
Disease Associations
Tissue Specificity Expressed in bone marrow. Not detected in placenta. {ECO:0000269PubMed:10318872}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
GO:0001694 histamine biosynthetic process
GO:0006955 immune response
GO:0017148 negative regulation of translation
GO:0019370 leukotriene biosynthetic process
GO:0042119 neutrophil activation
GO:0042554 superoxide anion generation
GO:0045416 positive regulation of interleukin-8 biosynthetic process
GO:0045575 basophil activation
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001304 C-type lectin
IPR002352 Eosinophil major basic protein
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS PR00770
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y2Y8
PhosphoSite PhosphoSite-Q9Y2Y8
TrEMBL
UniProt Splice Variant
Entrez Gene 10394
UniGene Hs.251386
RefSeq NP_006084
HUGO HGNC:9363
OMIM 606814
CCDS CCDS7954
HPRD 08434
IMGT
EMBL AF132209 AF304354 AP000781 AY358930 BC069126 BC101613 BC113411
GenPept AAD24471 AAG41952 AAH69126 AAI01614 AAI13412 AAQ89289