InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRG3

Summary

InnateDB Protein

IDBP-46520.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRG3

Protein Name

proteoglycan 3

Synonyms

MBP2; MBPH;

Species

Homo sapiens

Ensembl Protein

ENSP00000287143

InnateDB Gene

IDBG-46518 (PRG3)

Protein Structure

UniProt Annotation

Function

Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils. {ECO:0000269PubMed:10318872}.

Subcellular Localization

Cytoplasmic granule {ECO:0000269PubMed:10318872}. Note=Localized to the eosinophil secondary granule.

Disease Associations

Tissue Specificity

Expressed in bone marrow. Not detected in placenta. {ECO:0000269PubMed:10318872}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030246	carbohydrate binding

Biological Process

GO:0001694	histamine biosynthetic process
GO:0006955	immune response
GO:0017148	negative regulation of translation
GO:0019370	leukotriene biosynthetic process
GO:0042119	neutrophil activation
GO:0042554	superoxide anion generation
GO:0045416	positive regulation of interleukin-8 biosynthetic process
GO:0045575	basophil activation