InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANKRD11

Summary

InnateDB Protein

IDBP-47308.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANKRD11

Protein Name

ankyrin repeat domain 11

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000301030

InnateDB Gene

IDBG-47304 (ANKRD11)

Protein Structure

UniProt Annotation

Function

May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15184363, ECO:0000269Ref.1}.

Disease Associations

KBG syndrome (KBGS) [MIM:148050]: A syndrome characterized by macrodontia of the upper central incisors, distinctive craniofacial findings, short stature, skeletal anomalies, and neurologic involvement that includes global developmental delay, seizures, and intellectual disability. {ECO:0000269PubMed:21782149}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001894	tissue homeostasis
GO:0035264	multicellular organism growth
GO:0042475	odontogenesis of dentin-containing tooth
GO:0048705	skeletal system morphogenesis
GO:0060323	head morphogenesis
GO:0060325	face morphogenesis
GO:0060348	bone development