InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRKCZ

Summary

InnateDB Protein

IDBP-473488.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKCZ

Protein Name

protein kinase C, zeta

Synonyms

PKC-ZETA; PKC2;

Species

Homo sapiens

Ensembl Protein

ENSP00000426412

InnateDB Gene

IDBG-86108 (PRKCZ)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 171 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	171 [view]
Protein-Protein	170 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004697	protein kinase C activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0043560	insulin receptor substrate binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007596	blood coagulation
GO:0018105	peptidyl-serine phosphorylation
GO:0030010	establishment of cell polarity
GO:0030168	platelet activation
GO:0031333	negative regulation of protein complex assembly
GO:0032753	positive regulation of interleukin-4 production
GO:0035556	intracellular signal transduction
GO:0045630	positive regulation of T-helper 2 cell differentiation
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0046628	positive regulation of insulin receptor signaling pathway
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0060291	long-term synaptic potentiation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:2000463	positive regulation of excitatory postsynaptic membrane potential
GO:2000553	positive regulation of T-helper 2 cell cytokine production
GO:2000664	positive regulation of interleukin-5 secretion
GO:2000667	positive regulation of interleukin-13 secretion
GO:2001181	positive regulation of interleukin-10 secretion

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0030054	cell junction
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR017892 Protein kinase, C-terminal
IPR020454 Diacylglycerol/phorbol-ester binding
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00130
PF00433

PRINTS

PR00109
PR00008

PIRSF

SMART

SM00133
SM00109
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt