InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UIMC1

Summary

InnateDB Protein

IDBP-473692.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UIMC1

Protein Name

ubiquitin interaction motif containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000427480

InnateDB Gene

IDBG-59258 (UIMC1)

Protein Structure

UniProt Annotation

Function

Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269PubMed:12080054, ECO:0000269PubMed:17525340, ECO:0000269PubMed:17525341, ECO:0000269PubMed:17525342, ECO:0000269PubMed:17621610, ECO:0000269PubMed:17643121, ECO:0000269PubMed:19015238, ECO:0000269PubMed:19202061, ECO:0000269PubMed:19261748}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12080054, ECO:0000269PubMed:17525340, ECO:0000269PubMed:17525341, ECO:0000269PubMed:17525342, ECO:0000269PubMed:17621610, ECO:0000269PubMed:17643121}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).

Disease Associations

Tissue Specificity

Expressed in testis, ovary, thymus and heart. Expressed in germ cells of the testis. {ECO:0000269PubMed:12080054}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	78 [view]
Protein-Protein	78 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042393	histone binding
GO:0070530	K63-linked polyubiquitin binding

Biological Process

GO:0006302	double-strand break repair
GO:0006351	transcription, DNA-templated
GO:0010212	response to ionizing radiation
GO:0031572	G2 DNA damage checkpoint
GO:0045739	positive regulation of DNA repair
GO:0045892	negative regulation of transcription, DNA-templated
GO:0070537	histone H2A K63-linked deubiquitination