Version 5.4
Homo sapiens Protein: DOCK5
Summary
InnateDB Protein IDBP-473965.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOCK5
Protein Name dedicator of cytokinesis 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000429737
InnateDB Gene IDBG-12661 (DOCK5)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR011511 Variant SH3 domain
PFAM PF00018
PF14604
PF07653
PRINTS PR00452
PIRSF
SMART SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H7D0
PhosphoSite PhosphoSite-Q9H7D0
TrEMBL
UniProt Splice Variant
Entrez Gene 80005
UniGene Hs.717863
RefSeq
HUGO HGNC:23476
OMIM
CCDS
HPRD 09925
IMGT
EMBL AC041005 AC091185 AK024687 AK126249 BC011877 BC041761 BC137175 BC137176 CR627414
GenPept AAH11877 AAH41761 AAI37176 AAI37177 BAB14962 BAC86503 CAH10503

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca