InnateDB Protein
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IDBP-474026.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SH2D4A
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Protein Name
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SH2 domain containing 4A
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000429482
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InnateDB Gene
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IDBG-9465 (SH2D4A)
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Protein Structure
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Function |
Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function. {ECO:0000269PubMed:18641339, ECO:0000269PubMed:19712589}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:18641339}. Note=Located at podocyte foot processes. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. Aberrantly expressed in some cancers. {ECO:0000269PubMed:12476414}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0010923
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negative regulation of phosphatase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR000980
SH2 domain
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PFAM |
PF00017
PF14633
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PRINTS |
PR00401
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PIRSF |
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SMART |
SM00252
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H788
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PhosphoSite |
PhosphoSite-Q9H788
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
63898
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UniGene |
Hs.303208
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RefSeq |
NP_001167631
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HUGO |
HGNC:26102
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OMIM |
614968
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CCDS |
CCDS55206
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HPRD |
08340
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IMGT |
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EMBL |
AC068880
AK024620
AK024799
AK293301
AY190323
BC014525
BC067117
BC082982
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GenPept |
AAH14525
AAH67117
AAH82982
AAO41715
BAB14935
BAB15010
BAG56822
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