Homo sapiens Protein: DOK6
Summary
InnateDB Protein IDBP-4743.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOK6
Protein Name docking protein 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000372160
InnateDB Gene IDBG-4741 (DOK6)
Protein Structure
UniProt Annotation
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret- mediated neurite growth. May have a role in brain development and/or maintenance. {ECO:0000269PubMed:15286081}.
Subcellular Localization
Disease Associations
Tissue Specificity Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis. {ECO:0000269PubMed:15286081}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005158 insulin receptor binding
GO:0005515 protein binding
Biological Process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
IPR002404 Insulin receptor substrate-1, PTB
PFAM PF00169
PF02174
PRINTS PR00628
PIRSF
SMART SM00233
SM00310
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PKX4
PhosphoSite PhosphoSite-Q6PKX4
TrEMBL
UniProt Splice Variant
Entrez Gene 220164
UniGene Hs.685404
RefSeq NP_689934
HUGO HGNC:28301
OMIM 611402
CCDS CCDS32841
HPRD 13244
IMGT
EMBL AC026585 AK057795 AY599248 BC008583 BC019045 BC096744 CH471117
GenPept AAH08583 AAH19045 AAH96744 AAT09770 BAB71577 EAW66514