Homo sapiens Protein: GRK4 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-474411.4 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | GRK4 | ||||||||||||||||||
Protein Name | G protein-coupled receptor kinase 4 | ||||||||||||||||||
Synonyms | GPRK2L; GPRK4; GRK4a; IT11; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000427445 | ||||||||||||||||||
InnateDB Gene | IDBG-7807 (GRK4) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. {ECO:0000269PubMed:19520868, ECO:0000269PubMed:8626439}. | ||||||||||||||||||
Subcellular Localization | Cytoplasm. Cytoplasm, cell cortex. Note=Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where colocalization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 colocalize in lipid rafts of renal proximal tubule cells. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in myometrium. {ECO:0000269PubMed:16636192, ECO:0000269PubMed:8626439}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000239
GPCR kinase IPR000342 Regulator of G protein signalling domain IPR000719 Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR016137 Regulator of G protein signalling superfamily IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00615
PF00069 PF07714 |
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PRINTS |
PR00717
PR01301 PR00109 |
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PIRSF | |||||||||||||||||||
SMART |
SM00220
SM00315 SM00219 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | P32298 | ||||||||||||||||||
PhosphoSite | PhosphoSite-P32298 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 2868 | ||||||||||||||||||
UniGene | Hs.32959 | ||||||||||||||||||
RefSeq | NP_001004057 | ||||||||||||||||||
HUGO | HGNC:4543 | ||||||||||||||||||
OMIM | 137026 | ||||||||||||||||||
CCDS | CCDS33947 | ||||||||||||||||||
HPRD | 00656 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AK223581 BC117320 L03718 U33054 U33055 U33056 U33153 U33154 U33155 U33156 U33157 U33158 U33159 U33160 U33161 U33162 U33163 U33164 U33165 U33166 U33167 U33168 X75897 X97879 X97880 X97881 X98118 Z68192 | ||||||||||||||||||
GenPept | AAB04045 AAC50406 AAC50407 AAC50408 AAC50409 AAC50410 AAC50411 AAC50412 AAI17321 BAD97301 CAA53506 CAA66468 CAA66469 CAA66470 CAA66802 CAA92341 | ||||||||||||||||||