InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MATR3

Summary

InnateDB Protein

IDBP-474459.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MATR3

Protein Name

matrin 3

Synonyms

ALS21; MPD2; VCPDM;

Species

Homo sapiens

Ensembl Protein

ENSP00000423533

InnateDB Gene

IDBG-47535 (MATR3)

Protein Structure

UniProt Annotation

Function

May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. {ECO:0000269PubMed:11525732}.

Subcellular Localization

Nucleus matrix.

Disease Associations

Amyotrophic lateral sclerosis 21 (ALS21) [MIM:606070]: A neurodegenerative disorder affecting upper and lower motor neurons, resulting in muscle weakness and respiratory failure. Some patients may develop myopathic features or dementia. {ECO:0000269PubMed:19344878, ECO:0000269PubMed:24686783}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	80 [view]
Protein-Protein	80 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding