Version 5.4
Homo sapiens Protein: LRRTM2
Summary
InnateDB Protein IDBP-47474.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRRTM2
Protein Name leucine rich repeat transmembrane neuronal 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000274711
InnateDB Gene IDBG-47472 (LRRTM2)
Protein Structure
UniProt Annotation
Function Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized to excitatory synapses. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in neuronal tissues. {ECO:0000269PubMed:12676565}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042043 neurexin family protein binding
Biological Process
GO:0002091 negative regulation of receptor internalization
GO:0050808 synapse organization
GO:0060291 long-term synaptic potentiation
Cellular Component
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0045211 postsynaptic membrane
GO:0060076 excitatory synapse
Protein Structure and Domains
PDB ID
InterPro IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
PFAM PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43300
PhosphoSite PhosphoSite-O43300
TrEMBL
UniProt Splice Variant
Entrez Gene 26045
UniGene Hs.678651
RefSeq NP_056379
HUGO HGNC:19409
OMIM 610868
CCDS CCDS47272
HPRD 17454
IMGT
EMBL AB007876 AK291064 AY182026 BC126408 BC126410 BC143926
GenPept AAI26409 AAI26411 AAI43927 AAO67547 BAA24846 BAF83753

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca