Version 5.4
Homo sapiens Protein: PAIP2
Summary
InnateDB Protein IDBP-474807.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAIP2
Protein Name poly(A) binding protein interacting protein 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000422508
InnateDB Gene IDBG-47643 (PAIP2)
Protein Structure
UniProt Annotation
Function Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. {ECO:0000269PubMed:11172725}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:11172725}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030371 translation repressor activity
Biological Process
GO:0045947 negative regulation of translational initiation
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR009818 Ataxin-2, C-terminal
PFAM PF07145
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BPZ3
PhosphoSite PhosphoSite-Q9BPZ3
TrEMBL D6RA77
UniProt Splice Variant
Entrez Gene 51247
UniGene Hs.711542
RefSeq NP_001028284
HUGO HGNC:17970
OMIM 605604
CCDS CCDS4211
HPRD 05726
IMGT
EMBL AC011404 AC135457 AF151052 AF317675 AK314672 AL136640 BC001716 BC048106 BC062718 CH471062
GenPept AAF36138 AAH01716 AAH48106 AAH62718 AAK11562 BAG37228 CAB66575 EAW62107 EAW62108 EAW62111 EAW62112

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca