InnateDB Protein
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IDBP-474849.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RGS3
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Protein Name
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regulator of G-protein signaling 3
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Synonyms
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C2PA; RGP3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000420356
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InnateDB Gene
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IDBG-81812 (RGS3)
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Protein Structure
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Function |
Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269PubMed:10749886, ECO:0000269PubMed:11294858, ECO:0000269PubMed:8602223, ECO:0000269PubMed:9858594}.
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Subcellular Localization |
Cytoplasm. Nucleus. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Long isoforms are cytoplasmic and associated with the plasma membrane. Short isoforms are nuclear.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
26
[view]
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Protein-Protein |
25
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005096
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GTPase activator activity
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Biological Process |
GO:0000188
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inactivation of MAPK activity
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GO:0008277
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regulation of G-protein coupled receptor protein signaling pathway
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GO:0038032
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termination of G-protein coupled receptor signaling pathway
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GO:0043547
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positive regulation of GTPase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR000342
Regulator of G protein signalling domain
IPR016137
Regulator of G protein signalling superfamily
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PFAM |
PF00615
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PRINTS |
PR01301
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PIRSF |
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SMART |
SM00315
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TIGRFAMs |
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Modification |
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SwissProt |
P49796
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PhosphoSite |
PhosphoSite-P49796
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TrEMBL |
H7BXY1
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UniProt Splice Variant |
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Entrez Gene |
5998
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UniGene |
Hs.693972
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RefSeq |
NP_001263189
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HUGO |
HGNC:9999
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OMIM |
602189
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CCDS |
CCDS6798
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HPRD |
03720
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IMGT |
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EMBL |
AF463495
AF490838
AF490839
AF490840
AF493927
AF493941
AK074977
AK096840
AK128127
AK289666
AL137066
AL162727
AL359455
AY585192
BC019039
BC042555
CH471090
U27655
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GenPept |
AAC50394
AAH19039
AAH42555
AAL68829
AAM12641
AAM12655
AAM33253
AAM33254
AAM33255
AAT79495
BAC11328
BAC87285
BAF82355
BAG53374
CAC78977
CAH70102
CAH70103
CAH70841
CAH70843
CAH73877
CAH73879
CAH73880
EAW87388
EAW87391
EAW87392
EAW87393
EAW87398
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