InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DUSP26

Summary

InnateDB Protein

IDBP-474857.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUSP26

Protein Name

dual specificity phosphatase 26 (putative)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000429176

InnateDB Gene

IDBG-16661 (DUSP26)

Protein Structure

UniProt Annotation

Function

Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). {ECO:0000269PubMed:15796912, ECO:0000269PubMed:16581800, ECO:0000269PubMed:16924234, ECO:0000269PubMed:17001450}.

Subcellular Localization

Cytoplasm. Nucleus. Golgi apparatus.

Disease Associations

Tissue Specificity

Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer. {ECO:0000269PubMed:15796912, ECO:0000269PubMed:16581800, ECO:0000269PubMed:16924234, ECO:0000269PubMed:17001450}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0002039	p53 binding
GO:0004647	phosphoserine phosphatase activity
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045785	positive regulation of cell adhesion
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:1902310	positive regulation of peptidyl-serine dephosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR020405 Atypical dual specificity phosphatase, subfamily A
IPR020417 Atypical dual specificity phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00782

PRINTS

PR01909
PR01908

PIRSF

SMART

SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt