InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRPRB

Summary

InnateDB Protein

IDBP-475258.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRPRB

Protein Name

signal recognition particle receptor, B subunit

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000418401

InnateDB Gene

IDBG-57356 (SRPRB)

Protein Structure

UniProt Annotation

Function

Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.

Experimentally validated
Total	62 [view]
Protein-Protein	61 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding

Biological Process

GO:0006412	translation
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007264	small GTPase mediated signal transduction
GO:0010467	gene expression
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005881	cytoplasmic microtubule
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR019009 Signal recognition particle receptor, beta subunit
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00025
PF04670
PF09439

PRINTS

PR00315
PR00328

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y5M8