InnateDB Protein
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IDBP-475340.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SERINC5
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Protein Name
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serine incorporator 5
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000421665
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InnateDB Gene
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IDBG-31297 (SERINC5)
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Protein Structure
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Function |
Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in placenta, skeletal muscle, spleen, thymus, testis and peripheral leukocyte and is expressed weakly in the heart, liver and fetal brain. {ECO:0000269PubMed:12688535}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005016
Serine incorporator/TMS membrane protein
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PFAM |
PF03348
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86VE9
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PhosphoSite |
PhosphoSite-Q86VE9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
256987
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UniGene |
Hs.288232
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RefSeq |
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HUGO |
HGNC:18825
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OMIM |
614551
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CCDS |
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HPRD |
12828
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IMGT |
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EMBL |
AC010260
AC012636
AF498273
AK297467
BC101280
BC101281
BC101283
CH471084
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GenPept |
AAI01281
AAI01282
AAI01284
AAP06800
BAG59889
EAW95843
EAW95844
EAW95845
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