InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC17A1

Summary

InnateDB Protein

IDBP-475445.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC17A1

Protein Name

solute carrier family 17 (sodium phosphate), member 1

Synonyms

NAPI-1; NPT-1; NPT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000420546

InnateDB Gene

IDBG-66361 (SLC17A1)

Protein Structure

UniProt Annotation

Function

Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in kidney cortex, liver and brain but not in other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015293	symporter activity
GO:0015321	sodium-dependent phosphate transmembrane transporter activity

Biological Process

GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0006817	phosphate ion transport
GO:0035435	phosphate ion transmembrane transport
GO:0044341	sodium-dependent phosphate transport
GO:0046415	urate metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14916

PhosphoSite