InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLF3

Summary

InnateDB Protein

IDBP-475561.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLF3

Protein Name

Kruppel-like factor 3 (basic)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000421252

InnateDB Gene

IDBG-13485 (KLF3)

Protein Structure

UniProt Annotation

Function

Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR029033 Histidine phosphatase superfamily

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P57682

PhosphoSite

PhosphoSite-P57682

TrEMBL

UniProt Splice Variant

Entrez Gene

51274

UniGene

Hs.704504

RefSeq

HUGO

HGNC:16516

OMIM

609392

CCDS

HPRD

13920

IMGT

EMBL

AB024523 AF285837 BC030662 BC051687

GenPept

AAH30662 AAH51687 AAK27329 BAA92271